Elsevier

Drug Discovery Today

Volume 2, Issue 11, November 1997, Pages 487-498
Drug Discovery Today

Review
Design and discovery of HIV-1 integrase inhibitors

https://doi.org/10.1016/S1359-6446(97)01105-7Get rights and content

The rapid emergence of human immunodeficiency virus (HIV) strains resistant to available drugs implies that effective treatment modalities will require the use of a combination of drugs targeting different sites of the HIV life cycle. Integrase is emerging as a novel target for intervention by chemotherapeutics. As part of a program to develop novel antiviral agents, we have studied a large number of compounds with activity against HIV-1 replication in the National Cancer Institute (NCI) Antiviral Drug Program. In this review, we present a comprehensive review of all such inhibitors reported to date.

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