Research paperCYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines
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Co-culture model of Caco-2/HT29-MTX cells: A promising tool for investigation of phycotoxins toxicity on the intestinal barrier
2021, ChemosphereCitation Excerpt :In fact, it has been documented that phase I enzymes play a role in PTX2 detoxification (Alarcan et al., 2017; Ferron et al., 2016b). As HT29-MTX cells do not express CYP (Carrière et al., 1994; Gervot et al., 1996; Mahler et al., 2009; Barlovatz-Meimon and Ronot, 2014), this may explain the greater sensitivity of HT29-MTX cells to PTX2 compared to Caco-2 cells. In contrast, a decrease of viability (around 20%) was reported in differentiated Caco-2 cells exposed to 200 nM PTX2 (Alarcan et al., 2019), indicating that Caco-2 cells alone seem to be more sensitive to PTX2 than in co-culture with HT29-MTX cells.
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