Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 5, May 2013, Pages 1256-1268
ReviewNew insights into the function and regulation of mitochondrial fission
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Highlights
► Mitochondrial morphology is controlled by fusion and fission. ► Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. ► Mitochondrial fission plays an important role in apoptosis and mitochondrial quality control. ► Drp1 is regulated by various post-translational modifications. ► Mitochondrial fission deficiencies cause various human diseases.
Abbreviations
AKAP1
A kinase anchoring protein 1
Endo B1
endophilin B1
ER
endoplasmic reticulum
GDAP1
ganglioside-induced differentiation-associated protein 1
GED
GTPase effector domain
GFP
green fluorescent protein
KO
knockout
LRRK2
leucine-rich repeat kinase 2
MEF
mouse embryonic fibroblast
Mff
mitochondrial fission factor
MiD51
mitochondrial dynamics 51
MIEF1
mitochondrial elongation factor 1
MIM
mitochondrial inner membrane
Mfn2
mitofusin 2
MOM
mitochondrial outer membrane
NO
nitric oxide
PKA
cAMP-dependent protein kinase
RNAi
RNA interference
SUMO
small ubiquitin-like modifier
VD
variable domain
Keywords
Mitochondrial fission
Drp1
Apoptosis
Mitophagy
Post-translational modification
Neurodegenerative disease
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