Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

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Abstract

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure–activity relationships (SAR), and selectivity against several other PDE family members are described.

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure–activity relationships (SAR), and selectivity against several other PDE family members are described.

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