Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists
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Acknowledgments
S.S.K. was supported by a NIH-visiting fellowship, B.N. was supported by a post-baccalaureate IRTA fellowship. Functional assay data were provided by the National Institute on Mental Health-Psychoactive Drug Screening Program (PDSP) with special thanks to Drs. Linda Brady and Bryan Roth for their support. Also, the authors wish to acknowledge Dr. Jarda Wroblewski for his contributions through the PDSP contract and thoughtful discussion of the functional assay results. This work is supported by
References and notes (16)
- et al.
Trends Pharmacol. Sci.
(2001) - et al.
Neuropharmacology
(2002)et al.Psychopharmacology (Berl.)
(2003)et al.Neuropsychopharmacology
(2004) - et al.
J. Biol. Chem.
(2000)et al.Mol. Pharmacol.
(2003) - et al.
Annu. Rev. Pharmacol. Toxicol.
(1997) - et al.
Nat. Rev. Drug Discov.
(2005) - et al.
Nat. Neurosci.
(2001)
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