Structure–activity relationship studies of curcumin analogues
Graphical abstract
References and notes (44)
- et al.
Curr. Prob. Cancer
(2007) - et al.
Cancer Lett.
(2005) - et al.
Bioorg. Med. Chem.
(2006) - et al.
Curr. Opin. Cell Biol.
(1997) - et al.
Biochim. Biophys. Acta
(1994) - et al.
Eur. J. Cell Biol.
(2001) - et al.
Biochem. Pharmacol.
(2007) - et al.
Bioorg. Med. Chem.
(2002) - et al.
Bioorg. Med. Chem. Lett.
(2005) - et al.
Bioorg. Med. Chem.
(2005)
Bioorg. Med. Chem.
Bioorg. Med. Chem. Lett.
Bioorg. Med. Chem.
Bioorg. Med. Chem.
Tetrahedron Lett.
J. Pharm. Biomed. Anal.
Life Sci.
Anticancer Res.
Mol. Pharm.
J. Immunol.
Ann. N.Y. Acad. Sci.
Am. J. Physiol. Gastrointest. Liver Physiol.
Cited by (104)
Theoretical Analysis of the Properties of Monocarbonyl Curcumin Analogs
2023, Polycyclic Aromatic CompoundsPerspectives for synthetic curcumins in chemoprevention and treatment of cancer: An update with promising analogues
2021, European Journal of PharmacologyCitation Excerpt :FLLL12 has been screened for its activity against various cancer types such as head and neck, lung, breast, pancreatic and colorectal cancers. Initial screening suggests that FLLL12 is approximately 5–10 times more potent than the parent compounds against prostate (PC-3 and LNCaP) and breast cancer cell lines (MCF-7 and MDA-MB-231) (Fuchs et al., 2009). FLLL12 was also tested against 5 pancreatic cancer cell lines indicating that this analogue is 3-21-fold more potent in inducing apoptosis (Friedman et al., 2009).
Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system
2020, Pharmacological ResearchRecent advances of analogues of curcumin for treatment of cancer
2019, European Journal of Medicinal ChemistryPotential role of curcumin and its derivatives against alzheimer disease
2019, Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological PropertiesChemical Diversification of Natural Product Extracts
2018, Studies in Natural Products ChemistryCitation Excerpt :The structural modification of curcumin, one of the main representatives of the curcuminoid group, has received worldwide attention and has led to a number of bioactive derivatives [39–41]. Of these derivatives, only pyrazoles have been found to show antimicrobial [42], antitumor [43], and neurotrophic activities [44]. Knowing the potential of these types of molecules, Wu et al. [38] employed chlorophenylhydrazine to modify a curcuminoid-enriched ethyl acetate extract of Curcuma longa L. (Zingiberaceae) through chemical transformation of β-diketone functionalities.