Cancer Cell
Volume 17, Issue 6, 15 June 2010, Pages 574-583
ArticleEnhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator
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Highlights
► Ctr1 expression in human ovarian tumors is associated with platinum drug response ► A copper chelator increases cisplatin adducts selectively in tumors ► The copper chelator improves cisplatin efficacy in a mouse model of cervical cancer ► The chelator enhances cisplatin killing of human ovarian and cervical cancer cells
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