Chemistry & Biology
Volume 19, Issue 10, 26 October 2012, Pages 1340-1353
ArticleSelective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2
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Highlights
► SK2 potassium channels control pacemaker activity of cerebellar Purkinje cells (PC) ► NS13001 was identified as potent positive modulator of type SK2/3 channels ► Oral delivery of NS13001 alleviated symptoms of transgenic mice model of SCA2 ataxia ► NS13001 holds promise as a potential therapeutic agent for treatment of ataxia
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These authors contributed equally to this work
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