Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.
► Prohibitins regulate cell survival, metabolism, and inflammation ► Prohibitins act as a hub for many signaling pathways ► Prohibitin ligands are examined in cancer, Parkinson’s disease, and obesity
