Cell Metabolism
Volume 14, Issue 1, 6 July 2011, Pages 21-32
ArticleAkt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
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Graphical Abstract
Highlights
► mTORC1 is required for proper activation of hepatic SREBP1c by insulin ► LTsc1KO mice reveal that mTORC1 activation is not sufficient to induce hepatic SREBP1c ► An mTORC1-independent pathway is also required for hepatic SREBP1c induction by Akt ► Akt signaling suppresses Insig2a, a liver-specific inhibitor of SREBP1c
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Present address: Joslin Diabetes Center, Boston, MA 02115, USA
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Present address: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
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These authors contributed equally to this work
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