The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm
Section snippets
Acknowledgments
Zhang-Jin Zhang gratefully acknowledges the support of Theodore and Vada Stanley and the Stanley Medical Research Institute, Bethesda, MD, USA.
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2014, NeuropharmacologyCitation Excerpt :This has led to the hypothesis that the behavioral actions of SKF-83959 may be mediated by its unique actions at PLC/calcium signaling at D1-D2 heterodimers (Rashid et al., 2007a; Hasbi et al., 2009; Downes and Waddington, 1993; Deveney and Waddington, 1995; Fujita et al., 2010; Perreault et al., 2010; Arnt et al., 1992). This widespread belief that SKF-83959 is the first highly biased D1 ligand has led many to consider it an important probe for studying the mechanisms related to D1 signaling (Zhang et al., 2009, 2007, 2005, 2007; Yu et al., 2008, 2005; Perreault et al., 2011). We had previously used this compound, and contrary to its widely-cited pharmacology, consistently found that SKF-83959 was a partial agonist at D1-adenylate cyclase (Ryman-Rasmussen et al., 2005).
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2009, Schizophrenia ResearchCitation Excerpt :Automated activity was recorded for 60 min and the total distance traveled was calculated by Jiliang Vision software (Jiliang Co. Ltd., Shanghai, China). PPI of the acoustic startle response was measured as described previously (Barr et al., 2006; Zhang et al., 2005) in four startle chambers from Coulbourn Instruments (Whitehall, PA, USA). Briefly, following a 3-min acclimation period, animals were exposed to four different types of trial: a PULSE ALONE trial in which a 40 ms, 120 dB white noise burst was presented; three PREPULSE (79 dB, 83 dB, 87 dB) + PULSE trials in which 20 ms, 3 kHz sounds were presented for 100 ms, respectively, before the onset of a 120 dB pulse.
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A summer student from Wootton High School, Rockville, MD, USA.