Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice
Graphical abstract
Highlights
► A single morphine-induced behavioural sensitization is simple and convenient. ► Reveal mechanisms of histone acetylation on development of morphine sensitization. ► HDACs in rodents may regulate drug addiction-related behaviours. ► Open a new potential way toward treating drug abuse and dependence.
Section snippets
Acknowledgements
This work was supported by grants from National Nature Science Foundation of China (Nos. 30570653 and 30870894), National Basic Research Program of China (Nos. 2003CB515400 and 2009CB522000), 985 Program of China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) and Tianjin Medical University Science Foundation of China (No. 2010ky02). A.J.L. is a Senior Fellow supported by the National Health & Medical Research Council (Australia).
References (31)
- et al.
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Curr. Opin. Pharmacol.
(2008) - et al.
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity
Neuroscience
(2007) Inhibition of histone deacetylase activity by butyrate
J. Nutr.
(2003)- et al.
Morphine alleviates early stages of apoptosis in cultured CEM x174 cells infected with simian immunodeficiency virus
Cell Biol. Int.
(2003) A histone deacetylase regulates addiction
Neuron
(2007)- et al.
A single preexposure produces sensitization to the locomotor effects of cocaine in mice
Pharmacol. Biochem. Behav.
(1993) - et al.
Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice
Behav. Brain Res.
(2007) - et al.
Long-term blockade of the expression of cocaine sensitization by ondansetron, a 5-HT(3) receptor antagonist
Eur. J. Pharmacol.
(2000) - et al.
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
Neuron
(2005) Effects of interdose interval on ambulatory sensitization to methamphetamine, cocaine and morphine in mice
Eur. J. Pharmacol.
(1996)
Valproate prevents the induction, but not the expression of morphine sensitization in mice
Behav. Brain Res.
Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
Prog. Neurobiol.
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
J. Biol. Chem.
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Brain Res. Brain Res. Rev.
Intermittent versus continuous stimulation: effect of time interval on the development of sensitization or tolerance
Life Sci.
Cited by (40)
Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs
2021, Food and Chemical ToxicologyHistone Deacetylase Inhibitors and Psychiatric Disorders
2021, Epigenetics in PsychiatryEpigenetic Mechanisms of Opioid Addiction
2020, Biological PsychiatryCitation Excerpt :Similar potentiation is observed for morphine-induced locomotor sensitization when the inhibitor is infused into the ventrolateral orbitofrontal cortex (38) and for heroin-induced or morphine-induced CPP when HDAC inhibitors are infused in the amygdala or NAc (34,39). Only two studies have suggested opposite changes in behavior following HDAC treatment, but these authors used unconventional approaches to examine behavioral responses to opioids, such as sensitization to a single morphine injection (63) or intracerebroventricular delivery of conditioning doses of morphine (64). Further, intrastriatal infusion of a bromodomain inhibitor, which blocks the ability of readers to identify acetylated lysine residues, blunts heroin self-administration and heroin-seeking behavior (36).
Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors
2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Recruitment of the HAT p300 ensues and is subsequently followed by increased local histone H4 acetylation and transcription of p27 and c-fos (Kang et al., 2005). Recurring morphine exposure is sufficient to induce behavioral sensitization and enhance acetylation of H3K14 in the nucleus accumbens (NAcc) and basolateral amygdala (BLA) (Jing et al., 2011; Sheng et al., 2011; Wang et al., 2015; Chen et al., 2016). Notably, sub-effective doses of NaB and VPA, that do not affect locomotor activity, can increase acetylated histone H3 levels in the NAcc, inhibit acute morphine-induced hyperactivity, and reduce behavioral sensitization (Jing et al., 2011).