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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Nature volume 334, pages 124–129 (1988)Cite this article

Abstract

One of the cellular targets implicated in the process of transformation by the adenovirus E1A proteins is a 105K cellular protein. Previously, this protein had been shown to form stable protein/protein complexes with the E1A polypeptides but its identity was unknown. Here, we demonstrate that it is the product of the retinoblastoma gene. The interaction between E1A and the retinoblastoma gene product is the first demonstration of a physical link between an oncogene and an anti-oncogene.

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Author information

Author notes

  1. Peter Whyte

    Present address: Fred Hutchinson Cancer Center, 1124 Columbia Street, Seattle, Washington, 98104, USA

  2. Margaret Raybuck

    Present address: Amersham International pic., Forest Farm Industrial Estate, Whitchurch, Cardiff, UK

  3. Ed Harlow: To whom correspondence should be addressed.

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Peter Whyte, Karen J. Buchkovich, Margaret Raybuck & Ed Harlow

  2. Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, USA

    Jonathan M. Horowitz, Stephen H. Friend & Robert A. Weinberg

  3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Jonathan M. Horowitz, Stephen H. Friend & Robert A. Weinberg

  4. Division of Hematology-Oncology, The Children's Hospital, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Stephen H. Friend

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  1. Peter Whyte
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  7. Ed Harlow
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Whyte, P., Buchkovich, K., Horowitz, J. et al. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334, 124–129 (1988). https://doi.org/10.1038/334124a0

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