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Diadenosine phosphates and the physiological control of blood pressure

Nature volume 367, pages 186–188 (1994)Cite this article

Abstract

OUR understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides1, endothelial-derived relaxing factor2 and endothelin3. Unidentified vasopressive agents have been found in platelets4. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hex-aphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10−9 M; in aortic rings, contractions were elicited at 10−8 M.Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.

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Authors and Affiliations

  1. Medizinische Poliklinik, Albert Schweitzer Strasse 33, Münster, 48129, Germany

    Hartmut Schlüter, Elmar Offers, Gitte Brüggemann, Marcus van der Giet, Martin Tepel, Claus Spieker & Walter Zidek

  2. lnstitut fur Medizinische Physik, Albert Schweitzer Strasse 33, Münster, 48129, Germany

    Eckhard Nordhoff & Michael Karas

  3. Institut für Biochemie der Universität Münster, Albert Schweitzer Strasse 33, Münster, 48129, Germany

    Herbert Witzel

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  1. Hartmut Schlüter
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Schlüter, H., Offers, E., Brüggemann, G. et al. Diadenosine phosphates and the physiological control of blood pressure. Nature 367, 186–188 (1994). https://doi.org/10.1038/367186a0

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