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XLαs is a new type of G protein

Nature volume 372, pages 804–809 (1994)Cite this article

Abstract

THE GTP-binding proteins are well-known regulators of cellular functions1–4, including vesicular transport5–7. Cholera toxin, which is known to catalyse ADP-ribosylation of the as subunit of hetero-trimeric G proteins, stimulates secretory vesicle formation from the trans-Golgi network8. Here we describe a new cholera toxin target, an 'extra large' G protein (XLαs; Mr 92K) which consists of a new 51K XL-portion linked to a Gαs truncated at the amino terminus. XLαs is specifically associated with the trans-Golgi net-work and occurs selectively in cells containing both the regulated and the constitutive pathway of protein secretion. Hence, XLαs may mediate the effects of cholera toxin on secretory vesicle formation.

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Author notes

  1. Wieland B. Huttner: To whom corrrespondence should be addressed

Authors and Affiliations

  1. Institute for Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany

    Ralph H. Kehlenbach, Julia Matthey & Wieland B. Huttner

Authors
  1. Ralph H. Kehlenbach
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  2. Julia Matthey
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  3. Wieland B. Huttner
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Kehlenbach, R., Matthey, J. & Huttner, W. XLαs is a new type of G protein. Nature 372, 804–809 (1994). https://doi.org/10.1038/372804a0

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