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Dancing to the tune of chemokines

Nature Immunology volume 2, pages 129–134 (2001)Cite this article

Abstract

Since their discovery 13 years ago, chemokines have emerged as the most important regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane-domain receptors that are coupled to heterotrimeric Gi proteins. The common response of all cells to chemokine stimulation is chemotaxis. In addition, leukocyte activation triggers diverse signal transduction cascades; which cascade is triggered depends on the chemokine and receptor engaged. The selective activation of distinct pathways suggests that the receptors couple not only to G proteins but also to additional downstream effectors. This review discusses recent advances in the elucidation of the signal transduction that occurs in proximity to receptors and that leads to the early biochemical events in leukocyte activation.

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Figure 1: Coreceptor activity.
Figure 2: Chemokine receptor signaling.
Figure 3: Receptor aggregation state–regulated signaling.

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Acknowledgements

The author thanks B. Dewald for critical reading and comments. Supported by the Swiss Science Foundation (NFP-38) and the Helmut Horten Foundation.

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    Marcus Thelen

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Thelen, M. Dancing to the tune of chemokines. Nat Immunol 2, 129–134 (2001). https://doi.org/10.1038/84224

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