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GPCRs

Heterodimer-specific signaling

Nature Chemical Biology volume 11, pages 244–245 (2015)Cite this article

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Heterodimerization of G protein–coupled receptors can lead to the activation of intracellular pathways that are not triggered by either of the individual receptors. This property may lead to the development of new therapeutic approaches showcasing increased efficiency and selectivity.

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Figure 1: Each GPCR activates a set of intracellular pathways through heterotrimeric G proteins and β-arrestins.

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Authors and Affiliations

  1. Marc Parmentier is in Welbio and Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles, Campus Erasme, Brussels, Belgium.,

    Marc Parmentier

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  1. Marc Parmentier
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Correspondence to Marc Parmentier.

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Parmentier, M. Heterodimer-specific signaling. Nat Chem Biol 11, 244–245 (2015). https://doi.org/10.1038/nchembio.1772

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