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Orexin, drugs and motivated behaviors

A Corrigendum to this article was published on 01 December 2005

Orexins are known to regulate sleep and feeding, but a study in Nature now shows that they are also involved in drug-seeking behavior. This suggests a larger role for orexin-producing neurons as an interface between internal states and motivated behaviors.

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Figure 1: Pathways through which orexins may influence drug-seeking and other motivated behaviors.

Bob Crimi

References

  1. Guilleminault, C., Carskadon, M. & Dement, W.C. Arch. Neurol. 30, 90–93 (1974).

    Article  CAS  Google Scholar 

  2. Harris, G.C., Wimmer, M. & Aston-Jones, G. Nature, advance online publication 14 August 2005 (10.1038/nature04071).

  3. Crocker, A. et al. Neurology (in the press).

  4. Sakurai, T. et al. Cell 92, 573–585 (1998).

    Article  CAS  Google Scholar 

  5. Winsky-Sommerer, R. et al. J. Neurosci. 24, 11439–11448 (2004).

    Article  CAS  Google Scholar 

  6. Shalev, U., Yap, J. & Shaham, Y. J. Neurosci. 21, RC129 (2001).

    Article  CAS  Google Scholar 

  7. Piazza, P.V. & Le Moal, M.L. Annu. Rev. Pharmacol. Toxicol. 36, 359–378 (1996).

    Article  CAS  Google Scholar 

  8. Yamanaka, A. et al. Neuron 38, 701–713 (2003).

    Article  CAS  Google Scholar 

  9. Mileykovskiy, B.Y., Kiyashchenko, L.I. & Siegel, J.M. Neuron 46, 787–798 (2005).

    Article  CAS  Google Scholar 

  10. Lee, M.G., Hassani, O.K. & Jones, B.E. J. Neurosci. 25, 6716–6720 (2005).

    Article  CAS  Google Scholar 

  11. Driver-Dunckley, E., Samanta, J. & Stacy, M. Neurology 61, 422–423 (2003).

    Article  CAS  Google Scholar 

  12. Hara, J. et al. Neuron 30, 345–354 (2001).

    Article  CAS  Google Scholar 

  13. Estabrooke, I.V. et al. J. Neurosci. 21, 1656–1662 (2001).

    Article  CAS  Google Scholar 

  14. Yoshida, K., McCormack, S., España, R., Crocker, A. & Scammell, T. J. Comp. Neurol. (in the press).

Download references

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Scammell, T., Saper, C. Orexin, drugs and motivated behaviors. Nat Neurosci 8, 1286–1288 (2005). https://doi.org/10.1038/nn1005-1286

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