Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments

Kazuhito Tanabe; Zhouen Zhang; Takeo Ito; Hiroshi Hatta; Sei-ichi Nishimoto

doi:10.1039/B711244K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments

Kazuhito Tanabe,^a Zhouen Zhang,^ab Takeo Ito,^a Hiroshi Hatta^a and Sei-ichi Nishimoto*^a

Author affiliations

* Corresponding authors

^a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan
E-mail: nishimot@scl.kyoto-u.ac.jp

^b Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence, ASTEM, Kyoto 615-8510, Japan

Abstract

To address the specific challenges of cancer therapy and diagnosis, a number of approaches have been advocated for the development of tumor-targeting antitumor drugs/prodrugs and non-invasive tumor molecular imaging probes. These intelligent drugs and probes are constructed from multi-functional molecular systems. This review focuses on the molecular design of drugs and imaging probes that target tumor-specific microenvironments such as angiogenesis and hypoxia.

Download options Please wait...

Article information

DOI: https://doi.org/10.1039/B711244K
Article type: Perspective
Submitted: 23 Jul 2007
First published: 01 Oct 2007

Download Citation

Org. Biomol. Chem., 2007,5, 3745-3757

Permissions

Request permissions

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments

K. Tanabe, Z. Zhang, T. Ito, H. Hatta and S. Nishimoto, Org. Biomol. Chem., 2007, 5, 3745 DOI: 10.1039/B711244K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments

Abstract

Article information

Download Citation

Permissions

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments

Social activity

Search articles by author

Spotlight

Advertisements