Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site†
Abstract
The synthesis, biological evaluation and molecular modeling of a series of
* Corresponding authors
a
Department of Medicinal Chemistry & Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, USA 23298-0540
E-mail:
glen.kellogg@vcu.edu
Tel: +1 804 828-6452
b Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, Richmond, Virginia, USA 23173
c Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA 78229-3900
The synthesis, biological evaluation and molecular modeling of a series of
C. Da, N. Telang, K. Hall, E. Kluball, P. Barelli, K. Finzel, X. Jia, J. T. Gupton, S. L. Mooberry and G. E. Kellogg, Med. Chem. Commun., 2013, 4, 417 DOI: 10.1039/C2MD20320K
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