Targeting of PKA, PKC and protein phosphatases to cellular microdomains

doi:10.1054/ceca.1999.0072

Cell Calcium

Volume 26, Issue 5, November 1999, Pages 209-217

https://doi.org/10.1054/ceca.1999.0072 Get rights and content

Abstract

The intracellular responses to many distinct extracellular signals involve the direction of broad-based protein kinases and protein phosphatases to catalyse quite specific protein phosphorylation/dephosphorylation events. It is now clear that such specificity is often achieved through subcellular targeting of distinct pools of kinase or phosphatase towards particular substrates at specific subcellular locations. Given the dynamic nature of protein phosphorylation reactions, coordinated control of both kinase and phosphatases is often required and complexes formed by common scaffold or targeting proteins exist to direct both kinase and phosphatase to the same subcellular location. In many cases more than one kinase or phosphatase is required and binding proteins which target more than one kinase or phosphatase have now been identified. This review summarizes recent findings relating to the concept of targeting PKA, PKC and the major serine/threonine phosphatases, PP1, PP2A and PP2B, through the formation of multi-enzyme signalling complexes.

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Invited reviewTargeting of PKA, PKC and protein phosphatases to cellular microdomains

Abstract

Pharmacol Ther

Trends Cell Biol

J Biol Chem

J Biol Chem

J Biol Chem

Biochim Biophys Acta

J Biol Chem

J Biol Chem

FEBS Lett

J Biol Chem

Trends Biochem Sci

J Biol Chem

J Biol Chem

J Biol Chem

Trends Biochem Sci

FEBS Lett

Neuron

J Biol Chem

J Biol Chem

J Biol Chem

J Biol Chem

Curr Biol

J Biol Chem

Arch Biochem Biophys

Curr Biol

J Biol Chem

Neuron

Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons

Science

Signaling through scaffold, anchoring, and adaptor proteins

Science

Localization of A-kinase through anchoring proteins

Mol Endocrinol

A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP

Biochim Biophys Acta

Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase

Proc Natl Acad Sci USA

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

Nature

Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

Proc Natl Acad Sci USA

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Proc Natl Acad Sci USA

Invited review
Targeting of PKA, PKC and protein phosphatases to cellular microdomains