Invited reviewTargeting of PKA, PKC and protein phosphatases to cellular microdomains
References (71)
Cyclic nucleotide-dependent protein kinases
Pharmacol Ther
(1991)- et al.
AKAPs: from structure to function
Trends Cell Biol
(1999) - et al.
Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5
J Biol Chem
(1994) - et al.
Protein kinase A anchoring
J Biol Chem
(1997) - et al.
Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes
J Biol Chem
(1996) - et al.
Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules
Biochim Biophys Acta
(1998) - et al.
(1994) PKCu is a novel atypical member of the protein kinase C family
J Biol Chem
(1994) - et al.
Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway
J Biol Chem
(1997) - et al.
Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cells
FEBS Lett
(1998) - et al.
The coatomer protein beta’-COP, a selective binding protein (RACK) for protein kinase Cepsilon
J Biol Chem
(1997)
On target with a new mechanism for the regulation of protein phosphorylation
Trends Biochem Sci
Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatography
J Biol Chem
A protein phosphatase-1-binding motif identified by the panning of a random peptide display library
J Biol Chem
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo
J Biol Chem
Regulation of protein kinase cascades by protein phosphatase 2A
Trends Biochem Sci
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7: vpr
FEBS Lett
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A
Neuron
Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
J Biol Chem
The myeloid leukemia-associated protein SET is a potent inhibitor of proteinphosphatase 2A
J Biol Chem
HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A
J Biol Chem
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
J Biol Chem
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein
Curr Biol
Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes
J Biol Chem
Regulation of recombinant PKC alpha activity by protein phosphatase 1 and protein phosphatase2A
Arch Biochem Biophys
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
Curr Biol
12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer
J Biol Chem
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A
Neuron
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
Science
Signaling through scaffold, anchoring, and adaptor proteins
Science
Localization of A-kinase through anchoring proteins
Mol Endocrinol
A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP
Biochim Biophys Acta
Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase
Proc Natl Acad Sci USA
Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons
Nature
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
Proc Natl Acad Sci USA
Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase
Proc Natl Acad Sci USA
Cited by (87)
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport
2019, Journal of Biological ChemistryCitation Excerpt :The signal activating PP1α here is unknown. PTH occupancy of its cognate PTHR elicits prompt activation of PKA (85, 86) and of PKC (87), either of which could be an upstream signal for PP1α (88) and Ser290 dephosphorylation. As shown here, PTH action on NPT2A also requires Ser290 rephosphorylation.
Differential roles of PKC isoforms (PKCs) in GnRH stimulation of MAPK phosphorylation in gonadotrope derived cells
2018, Molecular and Cellular EndocrinologyCitation Excerpt :Alternatively, or in addition, selective PKCs may be targeted to different signaling scaffolds in a ligand- and cell-context-dependent manner, and the scaffolds may differ in their affinity to the various MAPKs. The importance of the scaffolds has been demonstrated in various systems (Sim and Scott, 1999; Chen et al., 2004; Buensuceso et al., 2005), including that of the GnRHR (Dobkin-Bekman et al., 2009; Navratil et al., 2003; Davidson et al., 2004). Studies are therefore in progress to compare the GnRH- and the PMA-activated signalosomes, in the hope of further resolving the above-mentioned fate of the various PKCs.
The Importance of Kinase–Phosphatase Integration: Lessons from Mitosis
2018, Trends in Cell BiologySubstrate affinity differentially influences protein kinase C regulation and inhibitor potency
2016, Journal of Biological ChemistryTwo functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition
2016, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids