Elsevier

Drug Resistance Updates

Volume 2, Issue 6, December 1999, Pages 403-414
Drug Resistance Updates

Regular Article
Regulation of pleiotropic drug resistance in yeast

https://doi.org/10.1054/drup.1999.0113Get rights and content

Abstract

This review focuses on the molecular mechanisms involved in the regulation of multiple drug resistance in the model yeast Saccharomyces cerevisiae and the pathogenic fungus Candida albicans. Recent developments in the study of the transcription factors Pdr1p, Pdr3p and Yap1p are reported. Understanding the molecular basis leading to multiple drug resistance is a prerequisite for the development of new antifungal therapeutics.

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