Hepatoprotective Activity of Phenylethanoids from Cistanche deserticola

Quanbo Xiong; Koji Hase; Yasuhiro Tezuka; Tadato Tani; Tsuneo Namba; Shigetoshi Kadota

doi:10.1055/s-2006-957387

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Planta Med 1998; 64(2): 120-125
DOI: 10.1055/s-2006-957387

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Hepatoprotective Activity of Phenylethanoids from Cistanche deserticola

Quanbo Xiong¹ , Koji Hase¹ , Yasuhiro Tezuka¹ , Tadato Tani² , Tsuneo Namba¹ , Shigetoshi Kadota¹

¹Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Toyama, Japan
²Research Laboratories for High Quality of Life, Sumitomo Metal Industries, Ltd., Kyoto, Japan

Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2′-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl₄-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl₄ or D-galactosamine (D-GaIN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl₄ in vivo

Key words

Cistanche deserticola - Orobanchaceae - phenylethanoids - carbon tetrachloride - D-galactosamine - hepatoprotective activity

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