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Horm Metab Res 1989; 21(3): 132-136
DOI: 10.1055/s-2007-1009172
Clinical

© Georg Thieme Verlag, Stuttgart · New York

The Combined Use of Insulin and Sulfonylurea Therapy in Patients with Non-Insulin Dependent Diabetes Mellitus

G. M. Reaven, Elizabeth Fraze, Nina Y. Chen, Claire Hollenbeck, Yii-Der Ida Chen
  • Department of Medicine, Stanford University School of Medicine, Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Palo Alto, California, U.S.A.
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Publication History

1988

1988

Publication Date:
14 March 2008 (online)

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Summary

This study was initiated in order to evaluate the clinical efficacy of glipizide treatment in 18 patients with non-insulin dependent diabetes mellitus in poor glycemic control with insulin. Insulin dose was kept constant, and various facets of carbohydrate and lipid metabolism were evaluated before and from 4-6 months after the addition of glipizide. The results indicated that fasting and postprandial glucose concentration were significantly (P < 0.001) reduced following glipizide treatment, associated with a commensurate fall in glycosylated hemoglobin concentration. The average fall in fasting plasma glucose concentration in the total patient group approximated 60 mg/dl, and the mean decrement in 8 of the 18 patients who had a fall of more than 70 mg/dl in fasting glucose was 93 mg/dl. These results demonstrate that the addition of glipizide to the treatment program of patients with non-insulin dependent diabetes mellitus poorly controlled on insulin can lead to substantial clinical benefit.

Key-Words

Glipizide - Diabetes Mellitus - Insulin - Fasting - Post-Prandial Glucose Concentration - Glycosylated Hemoglobin Concentration

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