Supplement: Isotretinoin—A State-of-the-Art Conference: Supported by an Educational Grant from Roche Dermatologics Inc.
Regulation of lipid and lipoprotein metabolism by retinoids

https://doi.org/10.1067/mjd.2001.113718Get rights and content

Abstract

Retinoids are small vitamin A-derived lipophilic compounds that influence a wide variety of developmental and metabolic processes. Retinoids exert their action by activating transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) subfamilies of nuclear receptors. Therapeutically, retinoids are used for the treatment of dermatological disorders and certain cancers. Dyslipidemia is a common side-effect of therapy with the currently available retinoids. This review summarizes our current understanding of the molecular mechanisms of regulation of lipid and lipoprotein metabolism by retinoids. (J Am Acad Dermatol 2001;45:S158-67.)

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This article is part of a supplement sponsored by Roche Dermatologics Inc. The conference “Isotretinoin: A State-of-the-Art Conference” was supported by Roche.

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