Supplement: Isotretinoin—A State-of-the-Art Conference: Supported by an Educational Grant from Roche Dermatologics Inc.Regulation of lipid and lipoprotein metabolism by retinoids☆
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2022, Cholesterol: From Chemistry and Biophysics to the ClinicOverexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells
2021, Biochemical PharmacologyCitation Excerpt :RXRs heterodimerize with other nuclear receptors such as liver oxysterol receptors, peroxisome proliferator-activated receptors, farnesol X receptor and retinoic acid receptors to influence glucose, triglyceride, bile acid and cholesterol homeostasis. Dysregulation of these homeostatic control pathways may lead to common metabolic disorders including diabetes, obesity and hyperlipidemia, which are often complicated by the development of atherosclerosis [1–4]. And RXR ligands have been found to exert cardioprotective effects by reducing atherosclerosis in apolipoprotein E knockout mice [5–7].
Hyperlipidemia secondary to acitretin therapy for lamellar ichthyosis associated with a NIPAL4 mutation improves on a plant-based diet and relapses on a standard Western diet
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This article is part of a supplement sponsored by Roche Dermatologics Inc. The conference “Isotretinoin: A State-of-the-Art Conference” was supported by Roche.