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Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by μ-opioid receptors

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  • Receptors And Channels
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Abstract

Orphanin FQ (OFQ), an endogenous peptide ligand of opioid receptor-like receptors (ORLs), has properties similar to traditional opioids. This peptide inhibits adenylyl cyclase and voltage-gated calcium channels but stimulates inwardly rectifying potassium channels. Among other actions, however, OFQ also has pharmacological functions that are different from, or even opposite to, those of opioids. For example, OFQ antagonizes the behavioral analgesic effects mediated by κ- and μ-opioid receptors. In a previous paper, we reported that OFQ antagonizes inhibition of calcium channels mediated by κ-opioid receptors. We report here that OFQ also antagonizes the inhibition of calcium channels mediated by μ-opioid receptor. Further, single-cell RT-PCR reveals that the antagonistic effect of OFQ is correlated with the presence of ORL1 mRNA in individual cells.

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Author notes

  1. Min Zhang

    Present address: Department of Biological Statistics and Computational Biology, Cornell University, 14853, Ithaca, NY

Authors and Affiliations

  1. Neuroscience Research Institute, Peking University, Beijing, China

    Min Zhang, Xiaomin Wang, Guoheng Xu, Hongwei Dong, Yingxin Yu & Jisheng Han

  2. Department of Physiology, Capital University of Medical Sciences, Beijing, China

    Xiaomin Wang

  3. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 14642, Rochester, NY

    Dabao Zhang

Authors
  1. Min Zhang
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  2. Xiaomin Wang
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  3. Dabao Zhang
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  4. Guoheng Xu
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  6. Yingxin Yu
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  7. Jisheng Han
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Correspondence to Min Zhang.

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Zhang, M., Wang, X., Zhang, D. et al. Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by μ-opioid receptors. J Mol Neurosci 25, 21–27 (2005). https://doi.org/10.1385/JMN:25:1:021

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  • DOI: https://doi.org/10.1385/JMN:25:1:021

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