(−)-Gossypol Inhibits Growth and Promotes Apoptosis of Human Head and Neck Squamous Cell Carcinoma In Vivo1
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This research was supported by National Institute of Dental and Craniofacial Research (NIDCR) grants DE00452-01 (N.J.D.), DE014620-01Al (B.S.H.), and R01 DE13346 (T.E.C.); National Cancer Institute (NCI) grant R01 CA83087 (C.R.B.); Department of Defense idea grant B0000914; the Susan G. Komen Breast Cancer Foundation; the CapCure Foundation (S.W.); the University of Michigan's NCI Cancer Center support grant 5 P30 CA46592; Head and Neck Cancer SPORE grant P50 CA97248; and NIDCD Research Center Core grant P30 DC05188 (multiple authors). S.J.W. and K.G.W. were funded by National Institutes of Health training grant T32 DC05356. S.W. has financial interests in Ascenta Pharmaceuticals, which is pursuing the production of (−)-gossypol and other compounds for clinical use.
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Keith G. Wolter and Steven J. Wang contributed equally to this manuscript.