Targeting Antiapoptotic Bcl-2 Family Members with Cell-Permeable BH3 Peptides Induces Apoptosis Signaling, Death in Head, Neck Squamous Cell Carcinoma Cells1,2
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Keywords
HNSCC
Bcl-XL
Bcl-2
BH3 peptides
apoptosis
Abbreviations
Ant
Antennapedia
DMEM
Dulbecco's modified Eagle's medium
EGFR
epidermal growth factor receptor
FITC
fluorescein isothiocyanate
HNSCC
head, neck squamous cell carcinoma
NF-κB
nuclear factor-kappaB
PARP
poly(ADP)-ribose polymerase
PI
propidium iodide
R8
polyarginine
STAT3
signal transducer, activator of transcription-3
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- 1
This article refers to supplementary material, which is designated by Figure W1, is available online at www.bcdecker.com.
- 2
This work was supported by a grant (R01-CA86980) from the National Institutes of Health, by a grant (P50-CA097190) from the University of Pittsburgh Specialized Program of Research Excellence (SPORE) in Head, Neck Cancer.
- 3
Current address: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Copyright © 2007 Neoplasia Press, Inc. Published by Elsevier Inc.