Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells
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Abbreviations
CRC
colorectal cancer
JAK
Janus kinase
MMP9
matrix metalloproteinase 9
STAT
signal transducer and activator of transcription
VEGF
vascular endothelial growth factor
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This work was supported by grants from the National Basic Research Program of China (973 program) (no. 2005CB522400), the National Science Fund for Distinguished Young Scholars to F.J.Y. (no. 30625034), and the National Nature Science Foundation of China to C.Y.X. (no. 30500235).
Copyright © 2008 Neoplasia Press, Inc. Published by Elsevier Inc.