ReviewChronopharmacology Focused on Biological Clock
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2021, Life SciencesCitation Excerpt :Most drugs cause alterations in the 24-h rhythms of biochemical, physiological, and behavioral processes in complex metabolic pathways such as drug absorption, transportation, conversion, and drug-metabolizing enzyme activities [23]. These factors are affected by the circadian clock [35]. An ideal drug must be neither disruptive nor affect these processes.
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2021, European Journal of Pharmaceutical SciencesCitation Excerpt :Metabolic enzymes and drug transporters in detoxification pathways are under the control of the circadian clock, and they show circadian rhythm at gene expression and protein level (Dibner et al., 2010; Lévi et al., 2010). It is known that the pharmacokinetic profiles of many drugs may vary depending on their administration time, and circadian changes in drug transporters appear to be the major cause (Bruguerolle et al., 2008; Lévi et al., 2010; Levi and Schibler, 2007; Ohdo, 2010, 2007). The intraperitoneal (i.p.) administration route is one of the more commonly used routes in many in vivo studies of disease models in rodents (Al Shoyaib et al., 2020).
Optimizing the dosing schedule of L-asparaginase improves its anti-tumor activity in breast tumor-bearing mice
2018, Journal of Pharmacological SciencesCitation Excerpt :The mean tumor volume 20 days after the start of the l-asparaginase treatment was approximately 40% smaller than that in saline-treated mice (Fig. 3C). Previous studies demonstrated that the efficacies of many drugs vary according to their administration time.10,11 Therefore, we also tested whether the anti-tumor activity of l-asparaginase was further enhanced by changing the dosing time.