Chemokine receptors and HIV-1: the fusion of two major research fields

Immunol Today. 1999 Feb;20(2):89-94. doi: 10.1016/s0167-5699(98)01396-6.

Abstract

Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Animals
  • CD4 Antigens / genetics
  • CD4 Antigens / physiology
  • CD4-Positive T-Lymphocytes / virology
  • Chemokines / physiology
  • Disease Progression
  • Gene Expression Regulation
  • HIV Envelope Protein gp120 / metabolism
  • HIV Infections / metabolism
  • HIV Infections / therapy
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / physiology*
  • Macaca mulatta
  • Macromolecular Substances
  • Macrophages / virology
  • Molecular Sequence Data
  • Rabies virus
  • Receptors, CCR2
  • Receptors, CCR5 / chemistry
  • Receptors, CCR5 / genetics
  • Receptors, CCR5 / physiology
  • Receptors, CXCR4 / chemistry
  • Receptors, CXCR4 / genetics
  • Receptors, CXCR4 / physiology
  • Receptors, Chemokine / chemistry
  • Receptors, Chemokine / genetics
  • Receptors, Chemokine / physiology*
  • Receptors, Cytokine / chemistry
  • Receptors, Cytokine / genetics
  • Receptors, Cytokine / physiology
  • Recombinant Fusion Proteins / metabolism
  • Structure-Activity Relationship
  • Vesicular stomatitis Indiana virus

Substances

  • CD4 Antigens
  • Chemokines
  • HIV Envelope Protein gp120
  • Macromolecular Substances
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, Chemokine
  • Receptors, Cytokine
  • Recombinant Fusion Proteins