Abstract
6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Humans
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Inhibitory Concentration 50
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Isoquinolines