Mild trimethylaminuria caused by common variants in FMO3 gene

Lancet. 1999 Sep 4;354(9181):834-5. doi: 10.1016/s0140-6736(99)80019-1.

Abstract

Mild to transient trimethylaminuria is caused by common variants in the FMO3 gene leading to greatly reduced enzyme activity in vivo. FMO3 deficiency may have clinical relevance well beyond unpleasant body odour.

Publication types

  • Letter

MeSH terms

  • Adult
  • Child
  • Genes, Recessive
  • Genetic Variation*
  • Humans
  • Metabolism, Inborn Errors / genetics
  • Metabolism, Inborn Errors / urine*
  • Methylamines / urine*
  • Mutation, Missense
  • Oxygenases / deficiency
  • Oxygenases / genetics*
  • Syndrome

Substances

  • Methylamines
  • Oxygenases
  • dimethylaniline monooxygenase (N-oxide forming)
  • trimethylamine