Abstract
Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and the beta2-adrenergic receptor, and of the existence of a larger 'superfamily' of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.
Publication types
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Historical Article
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arrestins / chemistry
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Arrestins / genetics
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Arrestins / metabolism
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Heterotrimeric GTP-Binding Proteins / metabolism
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History, 20th Century
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Hormones / pharmacology
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Humans
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Mutation
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Receptors, Adrenergic, beta / chemistry
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Receptors, Adrenergic, beta / genetics
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Receptors, Adrenergic, beta / history*
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Receptors, Adrenergic, beta / metabolism
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Rhodopsin / chemistry
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Rhodopsin / genetics
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Rhodopsin / history*
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Rhodopsin / metabolism
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Second Messenger Systems / drug effects
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Vision, Ocular
Substances
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Arrestins
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Hormones
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Receptors, Adrenergic, beta
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Rhodopsin
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Heterotrimeric GTP-Binding Proteins