Morphine tolerance after chronic intracerebroventricular injection in male and female mice

B Kest; E Hopkins

doi:10.1016/s0006-8993(00)03301-1

Morphine tolerance after chronic intracerebroventricular injection in male and female mice

Brain Res. 2001 Feb 16;892(1):208-10. doi: 10.1016/s0006-8993(00)03301-1.

Authors

B Kest¹, E Hopkins

Affiliation

¹ Department of Psychology and Center for Developmental Neuroscience, (4S-223), The College of Staten Island/City University of New York, 2800 Victory Blvd., Staten Island, New York, NY 10314, USA. kest@postbox.csi.cuny.edu

PMID: 11172766
DOI: 10.1016/s0006-8993(00)03301-1

Abstract

We compared morphine analgesia ED(50) values of male and female mice prior to (Day 1) and after (Day 4) 3 days of intracerebroventricular morphine injections. Increases in ED(50) values from Day 1 to Day 4, indicating tolerance, were of similar magnitude in both sexes. The data suggest that spinal opioid analgesic mechanisms, acting alone or in synergy with supraspinal loci, may contribute to pharmacodynamic explanations of sex differences in systemic morphine tolerance.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Analgesics, Opioid / administration & dosage
Analgesics, Opioid / pharmacology
Analysis of Variance
Animals
Cerebral Ventricles / drug effects
Cerebral Ventricles / physiology*
Drug Administration Schedule
Drug Tolerance*
Female
Injections, Intraventricular
Male
Mice
Morphine / administration & dosage
Morphine / pharmacology*
Sex Characteristics
Time Factors

Substances

Analgesics, Opioid
Morphine