TGF-beta signaling: positive and negative effects on tumorigenesis

Lalage M Wakefield; Anita B Roberts

doi:10.1016/s0959-437x(01)00259-3

TGF-beta signaling: positive and negative effects on tumorigenesis

Curr Opin Genet Dev. 2002 Feb;12(1):22-9. doi: 10.1016/s0959-437x(01)00259-3.

Authors

Lalage M Wakefield¹, Anita B Roberts

Affiliation

¹ Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, Room C629, 41 Library Drive, MSC 5055, Bethesda, Maryland 20892-5055, USA. Wakefiel@dce41.nci.nih.gov

PMID: 11790550
DOI: 10.1016/s0959-437x(01)00259-3

Abstract

TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.

Publication types

Review

MeSH terms

Animals
DNA-Binding Proteins / metabolism
Gene Dosage
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Neoplasms / etiology*
Neoplasms / genetics
Neoplasms / metabolism
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism
Receptors, Transforming Growth Factor beta / metabolism
Signal Transduction / physiology*
Transcription, Genetic
Transcriptional Activation
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta / metabolism
Transforming Growth Factor beta / physiology*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta