Identification of G protein-coupled receptor genes from the human genome sequence

FEBS Lett. 2002 Jun 5;520(1-3):97-101. doi: 10.1016/s0014-5793(02)02775-8.

Abstract

We have identified novel G protein-coupled receptors (GPCRs) with no introns in the coding region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 registered GPCRs for endogenous ligands; 50 novel GPCR candidates homologous to registered GPCRs for endogenous ligands; and 59 novel GPCR candidates not homologous to registered GPCRs. The total number of GPCRs with and without introns in the human genome was estimated to be approximately 950, of which 500 are odorant or taste receptors and 450 are receptors for endogenous ligands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • DNA / chemistry
  • DNA / genetics
  • Databases, Nucleic Acid
  • GTP-Binding Proteins / metabolism
  • Gene Expression Profiling
  • Genome, Human*
  • Humans
  • Male
  • Molecular Sequence Data
  • Olfactory Nerve / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA

Substances

  • GPR119 protein, human
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • DNA
  • GTP-Binding Proteins

Associated data

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