Abstract
A specific increase in the level of a single coactivator appears to enhance estrogen action with tamoxifen at some gene targets in uterine cells but not breast cells.
MeSH terms
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Animals
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Breast Neoplasms / drug therapy*
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Female
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Histone Acetyltransferases
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Humans
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Models, Biological
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Nuclear Receptor Coactivator 1
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Receptors, Estrogen / metabolism*
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Selective Estrogen Receptor Modulators / chemistry
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Selective Estrogen Receptor Modulators / pharmacology
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Selective Estrogen Receptor Modulators / therapeutic use*
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Signal Transduction
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Tamoxifen / pharmacology*
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Tamoxifen / therapeutic use
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Transcription Factors / physiology*
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Uterine Neoplasms / drug therapy*
Substances
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Receptors, Estrogen
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Selective Estrogen Receptor Modulators
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Transcription Factors
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Tamoxifen
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Histone Acetyltransferases
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NCOA1 protein, human
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Nuclear Receptor Coactivator 1