The secrets of selective estrogen receptor modulation: cell-specific coregulation

Cancer Cell. 2002 Apr;1(3):215-7. doi: 10.1016/s1535-6108(02)00050-8.

Abstract

A specific increase in the level of a single coactivator appears to enhance estrogen action with tamoxifen at some gene targets in uterine cells but not breast cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy*
  • Female
  • Histone Acetyltransferases
  • Humans
  • Models, Biological
  • Nuclear Receptor Coactivator 1
  • Receptors, Estrogen / metabolism*
  • Selective Estrogen Receptor Modulators / chemistry
  • Selective Estrogen Receptor Modulators / pharmacology
  • Selective Estrogen Receptor Modulators / therapeutic use*
  • Signal Transduction
  • Tamoxifen / pharmacology*
  • Tamoxifen / therapeutic use
  • Transcription Factors / physiology*
  • Uterine Neoplasms / drug therapy*

Substances

  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators
  • Transcription Factors
  • Tamoxifen
  • Histone Acetyltransferases
  • NCOA1 protein, human
  • Nuclear Receptor Coactivator 1