Successful treatment of a complicated case of neuroleptic malignant syndrome

Intensive Care Med. 2002 Jul;28(7):976-7. doi: 10.1007/s00134-002-1241-6. Epub 2002 Jun 7.

Abstract

Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Antipsychotic Agents / adverse effects
  • Dantrolene / therapeutic use
  • Disseminated Intravascular Coagulation / complications
  • Female
  • Fluid Therapy
  • Humans
  • Infusions, Intravenous
  • Italy
  • Monoamine Oxidase Inhibitors / administration & dosage
  • Monoamine Oxidase Inhibitors / adverse effects
  • Muscle Relaxants, Central / therapeutic use
  • Neuroleptic Malignant Syndrome / complications
  • Neuroleptic Malignant Syndrome / drug therapy*
  • Rhabdomyolysis / complications
  • Tranylcypromine / administration & dosage
  • Tranylcypromine / adverse effects
  • Treatment Outcome*
  • Trifluoperazine / administration & dosage
  • Trifluoperazine / adverse effects

Substances

  • Antipsychotic Agents
  • Monoamine Oxidase Inhibitors
  • Muscle Relaxants, Central
  • Trifluoperazine
  • Tranylcypromine
  • Dantrolene