Abstract
Ca(2+)-activated K(+) channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Chromaffin Cells / chemistry
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Chromaffin Cells / physiology
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Cochlea / chemistry
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Cochlea / physiology
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Large-Conductance Calcium-Activated Potassium Channels
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Molecular Sequence Data
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Muscle, Smooth / chemistry
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Muscle, Smooth / physiology
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Potassium Channels, Calcium-Activated / chemistry*
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Potassium Channels, Calcium-Activated / physiology*
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Protein Structure, Tertiary
Substances
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Large-Conductance Calcium-Activated Potassium Channels
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Potassium Channels, Calcium-Activated