Abstract
A diverse family of transcription factors bind to the cAMP-response elements found in a variety of mammalian and viral gene promoters. One of the members of this family, CREB, is being intensively studied so as to elucidate the mechanisms by which second messenger signal transduction pathways act to positively and negatively regulate transcription.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins / physiology*
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Gene Expression Regulation / physiology*
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Molecular Sequence Data
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Phosphorylation
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Signal Transduction / physiology
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Transcription Factors / physiology*
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Transcription, Genetic / physiology*
Substances
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins
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Transcription Factors