Abstract
The mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases mediates the response of cells to many extracellular stimuli such as cytokines and growth factors. These protein kinases include the extracellular signal-regulated protein kinases (ERK) and two stress-activated protein kinases (SAPK), the c-Jun N-terminal kinases (JNK), and the p38 MAPK. The enzymes are evolutionarily conserved and are activated by a common mechanism that involves a protein kinase cascade. Scaffold proteins have been proposed to interact with MAPK pathway components to create a functional signaling module and to control the specificity of signal transduction. Here we critically evaluate the evidence that supports a physiologically relevant role of MAPK scaffold proteins in mammals.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Animals
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Arrestins / metabolism
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Carrier Proteins / metabolism*
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Contractile Proteins / metabolism
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Dual-Specificity Phosphatases
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Filamins
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Humans
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MAP Kinase Kinase Kinase 1*
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MAP Kinase Kinase Kinases / metabolism
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MAP Kinase Signaling System / physiology*
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Mammals / metabolism
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Microfilament Proteins / metabolism
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Phosphoprotein Phosphatases
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Protein Kinases / metabolism
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Protein Tyrosine Phosphatases / metabolism
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beta-Arrestins
Substances
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Adaptor Proteins, Signal Transducing
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Arrestins
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Carrier Proteins
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Contractile Proteins
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Filamins
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LAMTOR3 protein, human
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MAPK8IP1 protein, human
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Mapk8ip protein, mouse
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Microfilament Proteins
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beta-Arrestins
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Protein Kinases
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KSR-1 protein kinase
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MAP Kinase Kinase Kinase 1
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MAP Kinase Kinase Kinases
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MAP3K1 protein, human
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Map3k1 protein, mouse
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Phosphoprotein Phosphatases
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DUSP7 protein, human
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Dual-Specificity Phosphatases
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Protein Tyrosine Phosphatases