The coactivator LXXLL nuclear receptor recognition motif

J Pept Res. 2004 Mar;63(3):207-12. doi: 10.1111/j.1399-3011.2004.00126.x.

Abstract

Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Crystallography, X-Ray
  • Estrogen Receptor alpha
  • Leucine / chemistry
  • Ligands
  • Molecular Conformation
  • Molecular Sequence Data
  • Oligopeptides / chemistry
  • Oligopeptides / metabolism
  • Receptors, Cytoplasmic and Nuclear / agonists
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Estrogen / agonists
  • Receptors, Estrogen / chemistry
  • Receptors, Estrogen / metabolism
  • Sequence Alignment
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism

Substances

  • Estrogen Receptor alpha
  • Ligands
  • Oligopeptides
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Estrogen
  • Transcription Factors
  • Leucine