Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Planta Med. 2004 Mar;70(3):269-72. doi: 10.1055/s-2004-818922.

Abstract

Five new ent-kauranoids, xindongnins C - G ( 1 - 5), together with five known ones, xindongnins A and B ( 6 and 7), melissoidesin G ( 8), dawoensin A ( 9), and glabcensin V ( 10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6 - 10 showed inhibitory effects against human tumor K562 cells with IC (50) values ranging from 0.3 to 7.3 microg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

Publication types

  • Letter

MeSH terms

  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Diterpenes, Kaurane / administration & dosage
  • Diterpenes, Kaurane / chemistry
  • Diterpenes, Kaurane / pharmacology*
  • Diterpenes, Kaurane / therapeutic use
  • Humans
  • Inhibitory Concentration 50
  • Isodon*
  • K562 Cells / drug effects
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes, Kaurane
  • Plant Extracts