Protein tyrosine phosphatases in the human genome

Andres Alonso; Joanna Sasin; Nunzio Bottini; Ilan Friedberg; Iddo Friedberg; Andrei Osterman; Adam Godzik; Tony Hunter; Jack Dixon; Tomas Mustelin

doi:10.1016/j.cell.2004.05.018

Protein tyrosine phosphatases in the human genome

Cell. 2004 Jun 11;117(6):699-711. doi: 10.1016/j.cell.2004.05.018.

Authors

Andres Alonso¹, Joanna Sasin, Nunzio Bottini, Ilan Friedberg, Iddo Friedberg, Andrei Osterman, Adam Godzik, Tony Hunter, Jack Dixon, Tomas Mustelin

Affiliation

¹ Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

PMID: 15186772
DOI: 10.1016/j.cell.2004.05.018

Abstract

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.

Publication types

Review

MeSH terms

Amino Acid Sequence / genetics
Gene Expression Regulation, Enzymologic / genetics*
Genome, Human*
Humans
Phosphorylation
Phylogeny
Protein Structure, Tertiary / genetics
Protein Tyrosine Phosphatases / classification
Protein Tyrosine Phosphatases / genetics*
Protein Tyrosine Phosphatases / metabolism*
Signal Transduction / genetics*
Tyrosine / metabolism*

Substances

Tyrosine
Protein Tyrosine Phosphatases