Abstract
We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Benzoquinones / chemical synthesis
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Benzoquinones / pharmacology
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Fluorides / antagonists & inhibitors
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Hydroquinones / antagonists & inhibitors*
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Models, Theoretical
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Naphthoquinones / chemical synthesis
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Naphthoquinones / pharmacology
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Structure-Activity Relationship
Substances
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Benzoquinones
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Hydroquinones
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Naphthoquinones
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Fluorides