Abstract
We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean +/- SD QTc increased by 12.4 +/- 23 ms (p <0.001) at 6 months, by 10.7 +/- 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Adult
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Arrhythmias, Cardiac / chemically induced*
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Arrhythmias, Cardiac / diagnosis
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Electrocardiography
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Female
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Humans
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Male
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Methadone / administration & dosage
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Methadone / adverse effects*
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Middle Aged
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Narcotics / administration & dosage
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Narcotics / adverse effects*
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Opioid-Related Disorders / complications*
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Prospective Studies