Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells

D M Lovinger

doi:10.1016/0304-3940(91)90192-v

Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells

Neurosci Lett. 1991 Jan 14;122(1):57-60. doi: 10.1016/0304-3940(91)90192-v.

Author

D M Lovinger¹

Affiliation

¹ Unit of Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.

PMID: 1711659
DOI: 10.1016/0304-3940(91)90192-v

Abstract

The effect of acute ethanol (EtOH) exposure on 5-HT3 receptor-mediated ion current was examined in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. EtOH potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner at concentrations (25-100 mM) which are achieved during EtOH intoxication in vivo.

MeSH terms

Ethanol / pharmacology*
Ion Channels / metabolism*
Neuroblastoma / metabolism*
Receptors, Serotonin / drug effects*
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / metabolism

Substances

Ion Channels
Receptors, Serotonin
Ethanol