The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites

Immunol Today. 1991 Mar;12(3):A13-6. doi: 10.1016/S0167-5699(05)80005-2.

Abstract

One early reaction of the host to infection with protozoan parasites is the secretion of an array of potent cytokines including tumor necrosis factor (TNF), interleukin (IL-1) and IL-6. The combined action of these cytokines causes fever, leukocytosis and the production of acute phase proteins such as C-reactive protein (CRP). These early responses contribute significantly to the outcome of infection by influencing the course of infection directly and by regulating the specific immune response to the parasite.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / biosynthesis
  • Animals
  • C-Reactive Protein / physiology
  • Fever / etiology
  • Host-Parasite Interactions
  • Humans
  • Interleukin-1 / physiology*
  • Interleukin-6 / physiology*
  • Leukocytosis / etiology
  • Mice
  • Protozoan Infections / complications
  • Protozoan Infections / immunology*
  • Protozoan Infections / physiopathology
  • Rabbits
  • T-Lymphocytes / immunology
  • Tumor Necrosis Factor-alpha / physiology*

Substances

  • Acute-Phase Proteins
  • Interleukin-1
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein