Abstract
In many developmental systems, growth factor signalling must be temporally and spatially regulated, and this is commonly achieved by growth factor antagonists. Here, we describe the expression patterns of newly identified growth factor inhibitors, Sprouty and Sef, in the developing ocular lens. Sprouty and Sef are both expressed in the lens throughout embryogenesis, and become restricted to the lens epithelium, indicating that lens cell proliferation and fibre differentiation may be tightly regulated by such antagonists. Future studies will be aimed at understanding how these negative regulatory molecules modulate growth factor-induced signalling pathways and cellular processes in the lens.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / physiology*
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Cell Proliferation*
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Epithelium / chemistry
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Epithelium / metabolism
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Humans
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Lens, Crystalline / cytology
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Lens, Crystalline / embryology*
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Lens, Crystalline / physiology
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Membrane Proteins / biosynthesis*
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Membrane Proteins / genetics
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Mice
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Rats
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Rats, Wistar
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Receptors, Interleukin / biosynthesis
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Receptors, Interleukin / genetics
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Receptors, Interleukin-17 / biosynthesis
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Receptors, Interleukin-17 / genetics
Substances
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IL17RD protein, human
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Il17rd protein, rat
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Membrane Proteins
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Nerve Tissue Proteins
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Receptors, Interleukin
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Receptors, Interleukin-17
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Spry2 protein, rat